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Lexington is the county seat of Davidson County, North Carolina, United States. As of the 2000 census, the city had a total population of 19,953. It is located in central North Carolina, twenty miles (32 km) south of Winston-Salem. Major highways include I-85, U.S. Route 29, U.S. Route 70, U.S. Route 52 (soon to be I-285) and U.S. Route 64. Lexington is part of the Piedmont Triad region of the state.

Lexington, Thomasville, and the rural areas surrounding them are slowly turning into bedroom communities for nearby cities such as Winston-Salem, Greensboro and High Point.